Search for a Cure
Search for a Cure
Phase 2 Trial Tests Intensified Antiretroviral Therapy plus Interleukin-7 for HIV Eradication
- Details
- Category: Approved HIV Drugs
- Published on Friday, 22 October 2010 14:17
- Written by Cytheris
Biopharmaceutical company Cytheris announced this week that it has started a clinical trial to evaluate an intensive antiretroviral and immune-modulator regimen designed to reduce -- and ideally eliminate -- HIV in latently infected reservoir cells. Participants will intensify their current suppressive regimen by adding the 2 newest antiretroviral drug classes, along with interleukin 7 (IL-7) to activate resting CD4 T-cells.
AIDS Policy Project Urges Community Action to Push for More HIV Cure Funding
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- Category: Search for a Cure
- Published on Friday, 08 October 2010 14:17
- Written by AIDS Policy Project
The AIDS Policy Project (APP), a recently formed activist group advocating for a cure for AIDS, is calling for community action to push politicians to fund research toward HIV eradication or a "functional cure" that can enable HIV positive people to remain healthy without antiretroviral therapy. APP recently issued a report stating that the National Institutes of Health devotes only about 3% of its budget for HIV cure research, but argues that it should be a top priority.
AIDS 2010: Cure for HIV Is Feasible and Necessary, Researchers Say
- Details
- Category: Search for a Cure
- Published on Tuesday, 20 July 2010 13:56
- Written by Liz Highleyman
Eradication of HIV -- the long sought cure for AIDS -- appears more scientifically feasible than ever before, researchers reported at a meeting sponsored by the International AIDS Society in the lead-up to the XVIII International AIDS Conference (AIDS 2010) taking place this week in Vienna. Speaking at the AIDS 2010 opening plenary, Sharon Lewin explained that universal life-long antiretroviral treatment is increasingly unsustainable, and finding a cure would be fiscally sound as well as beneficial to patients.
Combination of Integrase Promoter and Protease Inhibitor May Offer Novel Approach to HIV Eradication
- Details
- Category: Search for a Cure
- Published on Tuesday, 24 August 2010 14:17
- Written by BioMed Central
Combining peptides that increase integration of HIV genetic material into the host cell genome with the protease inhibitor saquinavir (Invirase, formerly known as Ro 31-8959) led to apoptosis, or programmed death of HIV-infected cells, resulting in "total extermination" of the virus, according to a laboratory study reported in the August 19, 2010 issue of AIDS Research and Therapy. The lethal mix did not appear to have an effect on non-infected cells, suggesting that it might be developed as a novel anti-HIV therapy.
Histone Deacetylase Inhibitor both Actives Latent CD4 Cells and Reduces Coreceptor Expression
- Details
- Category: Search for a Cure
- Published on Tuesday, 20 July 2010 13:56
- Written by Liz Highleyman
A histone deacetylase (HDAC) inhibitor that turns off suppression of latent HIV genes in resting CD4 T-cells has the potential to flush hidden virus out of reservoir cells and make it vulnerable to antiretroviral drugs, according to a laboratory study published in the May 2010 Journal of Acquired Immune Deficiency Syndromes. Researchers found that the HDAC inhibitor ITF2357 increased HIV gene expression up to 15-fold more that the related agent valproic acid.
More Articles...
- Stem Cell Gene Therapy Appears Safe, May Protect Cells against HIV Infection
- CROI 2010: ART Intensification with Maraviroc (Selzentry) or Raltegravir (Isentress) May Improve Immune Activation and Inflammation
- HIV Reservoir Found in Blood Progenitor Cells in Bone Marrow
- Bold Efforts to Find a Cure for HIV/AIDS and New Prevention Tools Are Urgently Needed, Says NIAID Head
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