HIV Vaccines
IAS 2017: Another HIV Vaccine Efficacy Trial Will Start This Year
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- Category: HIV Vaccines
- Published on Wednesday, 09 August 2017 00:00
- Written by Gus Cairns
A year ago, one of the biggest pieces of prevention news at the Durban International AIDS Conference was the announcement that a large HIV vaccine efficacy study would start in South Africa. HVTN 702, now running, is only the eighth human vaccine efficacy trial ever run in the history of the HIV epidemic, and the first since 2009.
CROI 2017: Spanish HIV Vaccine Induces Control Off ART in Nearly 40% of Recipients
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- Category: Search for a Cure
- Published on Monday, 20 February 2017 00:00
- Written by Gus Cairns
A so-called "HIV Conserv" vaccine has, for the first time, produced significant prolonged viral control in a large minority of recipients once they were taken off antiretroviral therapy (ART). So far, 1 participant has stayed off ART for 7 months without having to resume it, according to a report at the Conference on Retroviruses and Opportunistic Infections last week in Seattle.
HIVR4P 2016: Huge Diversity in HIV Vaccine Research Discussed at Prevention Conference
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- Category: HIV Vaccines
- Published on Sunday, 23 October 2016 00:00
- Written by Gus Cairns
The HIV vaccine research field is currently going through probably its most fertile and diverse period yet. A high proportion of presentations at the second HIV Research for Prevention conference (HIVR4P 2016) in Chicago last week were devoted to a multiplicity of different approaches scientists are taking towards making an effective vaccine.
[Produced in collaboration with aidsmap.com]
At the opening plenary, Georgia Tomaras of Duke University gave an overview of the field. It has been a long journey towards developing vaccines with even partial efficacy: the first trial of any kind was in 1987 and the first large efficacy trial -- which failed -- was in 2003. But the RV144 vaccine -- which in 2009 showed limited efficacy, reducing HIV infections among recipients by 31% (and 60% a year after its first dose) -- injected new energy into the field, not least because its effect seemed due to an unexpected kind of anti-HIV response.
At the International AIDS Conference (AIDS 2016) held in Durban in July researchers reported that a pilot study, HVTN100, of an RV144-type vaccine adapted to the strain predominant in South Africa it produced a stronger response than the original RV144 vaccine. This meant it had passed the criteria for being advanced to a large efficacy trial, HVTN 702. This will start next month -- the first HIV vaccine efficacy trial for 7 years, since HVTN 505 started in July 2009.
Combination HIV Vaccine Efficacy Trial Launches in South Africa
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- Category: HIV Vaccines
- Published on Wednesday, 30 November 2016 00:00
- Written by NIAID
A new HIV vaccine efficacy study -- the first in 7 years -- got underway this week in Cape Town, South Africa. The HVTN 702 trial will evaluate the safety and effectiveness of 2 experimental vaccines -- ALVAC-HIV and a gp120 protein subunit vaccine -- related to a combination that previously demonstrated modest efficacy in the RV144 trial in Thailand. The study aims to enroll more than 5400 sexually active adults and results are expected in late 2020.
Coverage of HIV Research for Prevention Conference (HIVR4P 2016)
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- Category: HIV Prevention
- Published on Saturday, 22 October 2016 00:00
- Written by HIVandHepatitis.com
HIVandHepatitis.com coverage of the 2016 HIV Research for Prevention Conference (HIVR4P 2016), October 17-21, in Chicago.
Conference highlights include current and experimental pre-exposure prophylaxis (PrEP), microbicide rings and other options, and investigational HIV vaccines.
Full listing of coverage by topic
10/22/16