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CROI 2015: 3-Drug ART Prevents Vertical HIV Transmission [VIDEO]

Pregnant women treated with a standard 3-drug antiretroviral therapy (ART) regimen were less likely to transmit HIV to their babies that those given only zidovudine (AZT; Retrovir) and nevirapine (Viramune), according to results from the PROMISE study presented at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.

[Mary Glenn Fowler, CROI, February 24, 2015]

"We had very low transmission rates les than 2% for both strategies, however there was significantly decreased transmission for the triple arms compared to the zidovudine arm," Mary Glenn Fowler from Johns Hopkins School of Medicine said at a CROI press conference. But the triple regimen was associated with an overall increase in moderate but not severe maternal adverse events, as well as a higher risk of moderate adverse pregnancy outcomes such as low birth weight and pre-term delivery.

SEE ALSO: CROI 2015: Triple-Drug Combination Superior for Preventing Mother-to-Child HIV Transmission

3/5/15

Reference

MG Fowler, M Qin, SA Fiscus, et al. PROMISE: Efficacy and Safety of 2 Strategies to Prevent Perinatal HIV Transmission
. 2015 Conference on Retroviruses and Opportunistic Infections. Seattle, February 23-24, 2015. Abstract 31LB.