Bone Loss

Highlights from 2013 ICAAC, IDWeek, and EACS Meetings

Latest Positive Pulse Newsletter

In this overview Paul Sax from Harvard Medical School and Mark Sulkowski from Johns Hopkins discuss selected highlights from this fall's Interscience Conference on Microbial Agents and Chemotherapy (ICAAC), IDWeek, and the European AIDS Conference. The newsletter is available to all for free, with continuing medical education (CME) credit available for physicians and nurses.alt

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Low CD4 Count Raises Risk of Heart Attack, Bone Loss

HIV positive people whose CD4 T-cell count falls below 200 cells/mm3 are at greater risk for myocardial infarction, though the heart attack rate is not elevated for people with counts of 500 cells/mm3 or more, researchers recently reported. Another study found that people with low CD4 counts have a higher likelihood of bone loss after starting antiretroviral therapy (ART).

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Low CD4 Count at Start of HIV Treatment Linked to Greater Bone Loss

People who had low CD4 T-cell counts when they started antiretroviral therapy (ART) were significantly more likely to experience bone loss after ART initiation, especially if they also had high viral load, researchers reported in the August 13, 2013, advance edition of Clinical Infectious Diseases.

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IDWeek 2013: HIV+ People Not on Antiretrovirals Are Prone to Inflammation-related Bone Loss

HIV positive people not taking antiretroviral therapy experienced more bone mineral density (BMD) loss at the hip and were somewhat more likely to develop osteopenia or osteoporosis than HIV negative individuals, researchers reported at the second IDWeek conference held recently in San Francisco. They also found that bone loss among people with HIV appeared to be linked to inflammation.

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IAS 2013: Studies Look at Second-Line Bone Changes, Fractures, and HIV- and HCV-Related Bone Loss

People with HIV experience less bone loss if they switch to a NRTI-sparing second-line regimen containing raltegravir, researchers reported last week at the 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013) this week in Kuala Lumpur. Other studies showed that HIV infection is associated with increased risk of hip fractures and shed light on different mechanisms of bone loss associated with HIV and hepatitis C.

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