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Efavirenz More Effective than Nevirapine for Children with HIV

HIV positive African children and adolescents treated with efavirenz (Sustiva) were less likely to experience virological failure than those using nevirapine (Viramune), according to a large comparative study published in the May 1, 2013, Journal of the American Medical Association. Nevirapine, however, is less expensive and more widely available for children in low-income countries.

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FDA Approves Efavirenz (Sustiva) for HIV+ Children Ages 3 Months to 3 Years

The U.S. Food and Drug Administration (FDA) announced on May 3 that it has approved a supplemental new drug application for use of efavirenz (Sustiva) by infants and young children with HIV. The new dosing recommendation includes the option to sprinkling capsule contents on food for children who are unable to swallow pills.

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CROI 2013: Second-line NRTI-sparing HIV Regimen Proves Equally Effective

A second-line antiretroviral regimen of lopinavir/ritonavir (Kaletra or Aluvia) and raltegravir (Isentress) proved just as effective as a regimen containing lopinavir/ritonavir and 2 or 3 nucleoside or nucleotide analogs in large study conducted in Australia, Africa, Latin America, and Asia, researchers from Sydney’s Kirby Institute reported this week at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.

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Atripla Label Adds Drug Interactions with Hepatitis C Protease Inhibitors Boceprevir and Telaprevir

The U.S. Food and Drug Administration (FDA) announced this week that the product label information for Atripla -- the HIV single-tablet regimen containing efavirenz/tenofovir/emtricitabine -- has been updated to include information about drug-drug interactions with the hepatitis C virus protease inhibitors boceprevir (Victrelis) and telaprevir (Incivek or Incivo).

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CROI 2013: Small Risk of Birth Defects Due to Efavirenz Confirmed in French Cohort

A large French study has found an elevated risk of some birth defects in children born to women exposed to some antiretroviral drugs during the first trimester of pregnancy, French researchers reported on at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) this month in Atlanta.

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